Therapeutic armamentarium against systemic fungal infections

ABSTRACTThe incidence of invasive fungal infections (IFIs) has been following an upward trend over time, due to a continuous increase in the number of patients at risk, while the prognosis remains poor. In the last 10 years, the lipidic formulations of amphotericin B, voriconazole and a new family of antifungal drugs, the echinocandins, have been added to the traditional antifungal agents, for decades limited to just a few drugs such as amphotericin B deoxycholate, flucytosine and, later, fluconazole and itraconazole. These additions have improved both the results and the understanding of antifungal therapy, while at the same time making it more complex, with new questions arising that remain to be answered. This article reviews the mechanisms of action, spectrum of activity, pharmacology, administration, adverse effects and indications of each of the antifungal agents currently commercialised for the treatment of IFI

Implementation of an extended ZINB model in the study of low levels of natural gastrointestinal nematode infections in adult sheep

Background: In this study, two traits related with resistance to gastrointestinal nematodes (GIN) were measured in 529 adult sheep: faecal egg count (FEC) and activity of immunoglobulin A in plasma (IgA). In dry years, FEC can be very low in semi-extensive systems, such as the one studied here, which makes identifying animals that are resistant or susceptible to infection a difficult task. A zero inflated negative binomial model (ZINB) model was used to calculate the extent of zero inflation for FEC; the model was extended to include information from the IgA responses. Results: In this dataset, 64 % of animals had zero FEC while the ZINB model suggested that 38 % of sheep had not been recently infected with GIN. Therefore 26 % of sheep were predicted to be infected animals with egg counts that were zero or below the detection limit and likely to be relatively resistant to nematode infection. IgA activities of all animals were then used to decide which of the sheep with zero egg counts had been exposed and which sheep had not been recently exposed. Animals with zero FEC and high IgA activity were considered resistant while animals with zero FEC and low IgA activity were considered as not recently infected. For the animals considered as exposed to the infection, the correlations among the studied traits were estimated, and the influence of these traits on the discrimination between unexposed and infected animals was assessed. Conclusions: The model presented here improved the detection of infected animals with zero FEC. The correlations calculated here will be useful in the development of a reliable index of GIN resistance that could be of assistance for the study of host resistance in studies based on natural infection, especially in adult sheep, and also the design of breeding programs aimed at increasing resistance to parasites

Comparison of Brans Promethee multicriteria decision method and Promethee modified by authors for the optimization of an erosion control integral plan in Chaco area in Salta province (Argentine)

Chaco area is situated in the Province of Salta at North West of Argentine. The desertification is a big problem. In order to mitigate the problem it is necessary to take into account not only pedologic criteria but the economical, environmental, cultural and sociological criteria. Six sub zones have been established following previous studies. Eight criteria and six alternatives have been introduced in the model. Following the results of the study carried out by a collaborative project between UPM and UCS financed by AECID (1) were established several initial matrix. Brans Promethee multicriteria decision method (MCDM) was applied and the authors modified that method introducing weights like in Electre metho

Continuous multi-criteria methods for crop and soil conservation planning on La Colacha (Río Cuarto, Province of Cordoba, Argentina)

Agro-areas of Arroyos Menores (La Colacha) west and south of Rand south of R?o Cuarto (Prov. of Cordoba, Argentina) basins are very fertile but have high soil loses. Extreme rain events, inundations and other severe erosions forming gullies demand urgently actions in this area to avoid soil degradation and erosion supporting good levels of agro production. The authors first improved hydrologic data on La Colacha, evaluated the systems of soil uses and actions that could be recommended considering the relevant aspects of the study area and applied decision support systems (DSS) with mathematic tools for planning of defences and uses of soils in these areas. These were conducted here using multi-criteria models, in multi-criteria decision making (MCDM); first of discrete MCDM to chose among global types of use of soils, and then of continuous MCDM to evaluate and optimize combined actions, including repartition of soil use and the necessary levels of works for soil conservation and for hydraulic management to conserve against erosion these basins. Relatively global solutions for La Colacha area have been defined and were optimised by Linear Programming in Goal Programming forms that are presented as Weighted or Lexicographic Goal Programming and as Compromise Programming. The decision methods used are described, indicating algorithms used, and examples for some representative scenarios on La Colacha area are given

Decision theories used in planning of areas around La Colacha basin in Córdoba (Argentine) considering natural and human hazards

The authors of U.P.M. have had relations with Argentine Universities and Administrations, in part with J.M.Cisneros that is Professor at Universidad Nacional de Rio Cuarto in Prov. de Córdoba Arg., and have applied Decision Theories with Mathematic tools for the planning of defences and uses of soils in these areas and especially of La Colacha bassin enlarged with larger areas around it as “Cuenca de los Arroyos Menores” at West and South of Rio Cuarto. These large flat lands have loess soils brought by winds from Los Andes that are much far at West, there is a very old line of not high mountains at West near the study area from which rivers flow with little slopes to somehow lower flat areas at West with some marshes. Rivers through loess get regressive erosions with rains forming kilometres long ditches in the loess called “cárcavas” some meters deep and quite large across otherwise flat agricultural lands, and J.M. Cisneros, that has numerous publications about local soil uses, has directed diverse genie rural works to halt the regression of some of them. Part of the study is about protection against floods and “cárcavas”. There are famous experiences and records of higher inundations of large areas by rivers. Latitude of Rio Cuarto is 31º25’ South, that area is temperate refreshed by south winds, Zonda föhn winds from West being hotter and drier, and there are monsoons and so winter in July is dry and summer and December has rains, that average 829mm per year. Wind erosion and fires occur frequently on these loess soils in winter. This is an excellent area for agriculture but some actual uses may be not sustainable in long term such as excesses with genetically engineered soy, and the authors have studied aided with mathematical models (ELECTRE I, PROMETHEE and Expert Choice) the preferences of various alternative systems of land use (Autochthonous forest, High value forest, Traditional farms, Erosion control Crop with agriculture use, and Erosion control Crop with industrial use (biomass) ) in view of diverse Criteria (Water erosion index, Eolian erosion index, Implementation facility, Water resources, Economical Benefits, Hand power, Environmental Impacts, social Acceptance), as contribution for territorial planning, in part in relation with local official agencie

Sustainable agriculture using an intellingent mechatronic system

The goal of the Project group created by U.P.M. in collaboration with Foreign Universities, Research Institutions and Companies is the development of an intelligent mechatronic system for the use of precision and sustainable agriculture. The project as a whole includes the following components: photographing and decoding of the soil surface; fertility determination and formation of the fertility map; generation of the controlling signal for mechatronic dosing device; intelligent dosing of fertilizers; simulation, prototype and testing; human-machine interaction and training preparation

Mathematical Model to Select the Optimal Alternative for an Integral Plan to Desertification and Erosion Control for the Chaco Area in Salta Province (Argentine)

Multi-criteria Decision Analysis (MCDA) is concerned with identifying the values, uncertainties and other issues relevant in a given decision, its rationality, and the resulting optimal decision. These decisions are difficult because the complexity of the system or because of determining the optimal situation or behavior. This work will illustrate how MCDA is applied in practice to a complex problem to resolve such us soil erosion and degradation. Desertification is a global problem and recently it has been studied in several forums as ONU that literally says: "Desertification has a very high incidence in the environmental and food security, socioeconomic stability and world sustained development". Desertification is the soil quality loss and one of FAO's most important preoccupations as hunger in the world is increasing. Multiple factors are involved of diverse nature related to: natural phenomena (water and wind erosion), human activities linked to soil and water management, and others not related to the former. In the whole world this problem exists, but its effects and solutions are different. It is necessary to take into account economical, environmental, cultural and sociological criteria. A multi-criteria model to select among different alternatives to prepare an integral plan to ameliorate or/and solve this problem in each area has been elaborated taking in account eight criteria and six alternatives. Six sub zones have been established following previous studies and in each one the initial matrix and weights have been defined to apply on different criteria. Three Multicriteria Decision Methods have been used for the different sub zones: ELECTRE, PROMETHEE and AHP. The results show a high level of consistency among the three different multicriteria methods despite the complexity of the system studied. The methods are described for La Estrella sub zone, indicating election of weights, Initial Matrixes, the MATHCAD8 algorithms used for PROMETHEE, and the Graph of Expert Choice showing the results of AHP. A brief schema of the actions recommended for each of the six different sub zones is reported in Conclusions, with "We can combine Autochthonous and High Value Forest" for La Estrell

Are Comorbidities Associated With Overall Survival in Patients With Oral Squamous Cell Carcinoma?

Purpose: Oral squamous cell carcinoma (OSCC) is a highly prevalent type of immunogenic cancer with a low survival rate in patients with comorbidities owing to toxic habits. Materials and Methods: A retrospective cohort study was conducted of patients with resectable OSCC at a tertiary Spanish hospital from 2011 to 2014. The primary predictor variables were comorbidity and immune biomarkers. Comorbidity was assessed using the Adult Comorbidity Evaluation–27 (ACE-27) and scored from 1 to 3 (mild to severe decompensation, respectively). The immune biomarkers were neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR). The primary outcome variable was 5-year overall survival (OS). Other study variables were stage, margin, and neck management. Receiver operating characteristic curves were built for each ratio. For the survey of immune biomarkers, area under the curve was computed to determine cutoff points and investigate their association with OS. Kaplan-Meier estimates of survival and Cox proportional hazards models were used for longitudinal analysis. Results: Overall 215 patients were identified (median age, 67 yr; range, 32 to 96 yr; median follow-up, 31 months; range, 7 to 78 months); 159 patients had at least 1 comorbid condition. Results showed that a severe comorbidity (according to the ACE-27) increased the risk of death by 4 times in patients with OSCC regardless of stage. NLR, dNLR, LMR, and PLR were associated with OS in the univariate study. Cutoff points to predict increased mortality were 3, 1.9, 2.6, and 66 for NLR, dNLR, LMR, and PLR, respectively. Age, comorbidity, stage, margins, and management of the neck were important independent predictors of decreased OS in OSCC. PLR was marginally associated with OS in the multivariate model. Conclusion: These results suggest that comorbidity and NLR, dNLR, LMR, and PLR are associated with 5-year OS in patients with resectable OSCC

Territorial plannnig in a river basin with high erosion level using multicriteria decision methods in cordoba province(argentine)

The erosion-sedimentation-flooding processes in large zones of Argentine are a critical problem that involve complex relationships with technological, economic, social and environmental cause-effect. The increasing of agricultural activities in new areas previously with forestry or pasture could produce irreversible environmental impacts. It is necessary to prepare a spatial plan taking into consideration, economic development, social cohesion, environmental quality and progressive desertification. Multicriteria decision models contribute to the elaboration of that plan and provide an inestimable aid to decision makers. The objective of this paper is to elaborate a multicriteria model applied to the La Colacha Basin (Cordoba-Argentine). La Colacha Basin has 416 km2, it is a representative basin of a dry-sub-humid area where agriculture practices are progressively increased. Ten alternatives have been evaluated combining: (a) Agro-forest-pastoral (ASP), Present use (ACT) e Intensive use (INT), (b) with or without Soil conservation (CS), y (c) with or without Hydrological arrangement of the basin (OH). There have been selected 13 criteria. Different Multi-criteria Decision Methods, both of traditional or developed by the authors, have been used

An innovative quick solidifying technique for the forensic investigation of brain circulation using addition silicones

Post-mortem study of the brain is extremely relevant to medico-legal autopsies. However, it can be difficult to handle due to its fragility. This article presents a study on the development of an arterial solidifying technique that can be applied to analyze arterial circulation, consequently easing the handling and later diagnosis of diseases in this anatomical site. Vinylpolysiloxane silicone is introduced into the internal carotid arteries until it completely fills the arterial tree, creating a detailed model of the arterial's internal anatomy. This technique is fast, easy to apply and requires no previous tissue fixation. In addition, it allows for further toxicological and pathological tests. In conclusion, this technique represents a simple, sensitive and efficient method to employ in conventional autopsies, which can help in the diagnosis of death